On a Computational framework for Multiscale Blood Flow Applications

Dr. Marc Garbey
Friday, February 3, 2006
1:30PM - 3:00PM in HPA-112

Abstract


Numerical simulations are currently extensively used to analyze complex phenomena relevant to vascular diseases. The initial formation of arteriosclerosis plaque, for example, depends on the combination of various factors. The impact of physical and geometrical properties is well documented experimentally. There is also substantial evidence relating shear stress to the patho-physiology of arteriosclerosis: arteriosclerosis plaques are frequently located at or near regions of bifurcations, multiple intersections, and high vessel wall curvatures. However, arteriosclerosis is a slow process influenced accumulatively over years by many parameters, including chemical agents, mutagens, hypoxemia, immunological factors, and microbiological factors such as bacteria, virus, or endotoxins. On the other hand, these agents act on a much shorter time scale and in a localized manner. Therefore, in order to perform realistic simulations for cardiovascular physiology, one must address issues related to fluid and vessel wall interactions, and coupling of the aforementioned disparate time scales and length scales along with individual physiological conditions.

We will present a computational framework for blood flow simulation in main vessel that includes:

  • A fast prototyping method to combine image analysis and flow simulation on a parallel architecture.
  • A domain decomposition methodology to address the problem of multi-scale.
  • Some tools to address the issue of solution verification.

Short Bio


a. Education
Maitrise (Mathematics) Univ. of Lyon1, 1977.
Teaching Degree (High School Teacher), 1979.
Degree in Computer Science, Univ. of Grenoble 1981.
PHD (Applied Mathematics) Ecole Centrale de Lyon, 1984.
Habilitation (Applied Mathematics) , Univ. of Lyon1, 1989.

b. Academic Positions
Teacher in High School, 1978-1984.
Maitre de Conference, Univ. of Valencienne, 84-87.
Visiting Scientist, Argonne Nat Lab and Northwestern Univ. 87-88.
Maitre de Conference, Ecole Normale Sup. of Lyon, 88-90.
Professor in Applied Mathematic, Univ. of Lyon1, 90-
Scientific Consultant, Inria of Lorraine, 95-97
Professor in Computer Science, Univ. of Houston, 01-
Adjoint professor in the dept. of Mathematic at Univ. of Houston, 02-
Affiliated Professor in the dept. of Mechanical and Aerospace Engineering at University of Florida, Gainesville, 03-05
Adjoint Professor in the dept. of Engineering Technology, College of Technology, University of Houston, 04-
Chairman of the department of Computer Science of UH, 09/04-

c. Synergistic Activities
Founder and Director of the Center for the Development of Applications of Parallel Computing (CDCSP . http://cdcsp.univ-lyon1.fr) 1994-2001. This Research facility is used to transfer knowledge between disciplines in computational sciences and offer special short courses on parallel computing focussed on applications.
Co-Founder with A. Bourgeat and Chairman of the Lab of Modeling and Computational Sciences (MCS, http://mcs.univ-lyon1.fr) 1999-2002.
Director of CISM, a networking and new information technology service of University of Lyon and INSA 1995-2000.
Founder of a new lab in Modeling and Computational Science in the Department of Computer Science at University of Houston in January 2002: the main goal is to develop interdisciplinary projects between applied mathematicians and computer scientists with applications in biology, medicine and environmental sciences .

d. Former and Current Students
Former PhD in Applied Math (Univ of Lyon): A.Taik (95), A.Elhamidi (96), H.Outouzzalt (96), A.Mansour (97), Master Students who graduated me at UH in Math: C.Cussaguet, F.Dupros, M.Voyes (02)
Y.Jobic, E.Rougetet (03), A.Elkadi, C.Hamon, B.Hadri, H.Ltaief, M.Zerguine (04).
Current PhD students: F. Pacull (UH Math and University of Lyon Math), C.Picard (COSC-UH and University of Bordeaux in Math), B.Hardi (COSC-UH), H.Ltaief (COSC-UH).

e. Recent sponsored projects:

  • As a PI: Efficient Algorithm for Metacomputing of PDE . NSF for the period: 02/01/2003-01/03/2006
  • As a PI: Robust Aposteriori Error Estimate for Thermal Transport and Fluid Mechanics Applications . DOE for the period: 09/01/03-08/31/06
  • As a co-PI (with I.Pavlidis PI): Thermal Facial Screening . Honeywell International for the period 03/01/03-08/30/05.
  • As a PI with R.Keller (HLRS-Stuttgart), Y.Vassilevski (INM-Moscow) and Frank Hülsemann (Erlangen): Improving the reliability of computer simulations to predict environmental risks, NATO for the period 09/01/04-08/01/06.
  • As a Pi with I.Kakadiaris, H.Melki, I. Pavlidis and G.Zouridakis, Large .Scale Integration of Different Data Modalities for Computational Medical Sciences, Microsoft for the period 10/01/04-10/01/05.
  • As a co-Pi with G.Zouridakis (PI), I.Kakdiaris, I.Pavlidis, R.Vilalta, Acquisition of an Hybrid System and Research Infrastructure for Large-Scale Integration of Biomedical Data, Major Research Instrumentation Grant from NSF 08/01/05-07/30/07.