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Discovery of motifs and motif modules in DNA sequences
Dr. Xiaoman Shawn Li
Thursday, February 7, 2008
12:00PM ~ 1:00PM, BA-1-221
Abstract
Identifying motifs and motif modules is critical to understand gene
regulation. Available methods can not be readily applied to high
eukaryotes because they either cannot identify motifs and motif
modules in non-promoter regions, or they can not identify divergent
motifs and motif modules. We have thus developed novel methods to
identify motifs and motif modules in high eukaryotes. Besides, we have
designed unique ways to assess the reliability of the identified
motifs and motif modules. Without necessity of doing multiple
alignment, our methods can not only identify motifs and motif modules
on the whole genome scale, but also can detect motifs and motif
modules across very distant species. Compared with existing motif and
motif module identification methods, our methods show much better
performance.
Short Bio
Dr. Xiaoman Li is an Assistant Professor at School of Medicine,
Indiana University. After receiving his PhD in Mathematics from the
University of Southern California under the supervision of Dr. Michael
S. Waterman, Dr. Li carried out his postdoctoral research at the Wong
Lab at Harvard University then at Stanford University from 2003 to
2005. His research focuses on gene regulation, developmental biology
and evolution.
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